Lille Score Calculator
Calculate the Lille score and treatment response category using age, laboratory results, and bilirubin change. Lille Score Calculator helps clinicians assess corticosteroid response and prognosis in people with severe alcoholic hepatitis.
Highlights
- Calculates the validated Lille score for severe alcoholic hepatitis.
- Assesses likely response to corticosteroid treatment.
- Uses age, albumin, bilirubin, creatinine, and prothrombin time.
- Includes bilirubin measurements from day 0 and day 7.
- Provides a treatment response category and prognostic insight.
Table of Contents
How Lille Score Calculator Works?
The Lille Score Calculator estimates response to corticosteroid treatment in people with severe alcoholic hepatitis. It combines the patient's age, baseline albumin, baseline and day-7 bilirubin, renal function, and baseline prothrombin time. The result is converted through a logistic equation to produce a score between 0 and 1.
First, renal insufficiency is represented as a binary variable: 1 when serum creatinine is above 1.3 mg/dL or clinically indicates renal insufficiency, and 0 otherwise. The intermediate value is then calculated as:
The final Lille score is obtained by applying the logistic transformation:
The calculator uses the bilirubin change from day 0 to day 7, so a falling bilirubin generally lowers the score and suggests a better biochemical response. A Lille score below 0.45 is commonly interpreted as treatment response, while a score of 0.45 or higher indicates poor or absent response and increased short-term mortality risk.
| Lille score | Typical interpretation |
|---|---|
| < 0.45 | Likely corticosteroid responder |
| ≥ 0.45 | Poor or non-responder; reassess treatment and prognosis clinically |
Practical Use Cases
Hepatologists and gastroenterologists: Use the score after seven days of corticosteroid therapy to evaluate bilirubin evolution and support decisions about continuing or reconsidering treatment in severe alcoholic hepatitis.
Hospital physicians: Enter the admission laboratory values and day-7 bilirubin result to obtain a structured estimate of short-term treatment response during inpatient care.
Clinical pharmacists: Use the calculated response category as one clinical reference when reviewing corticosteroid effectiveness, renal status, and the need for therapy reassessment.
Researchers and trainees: Apply the equation to understand how age, albumin, bilirubin change, renal insufficiency, and prothrombin time contribute to the validated Lille prognostic model.
Patients and caregivers: Use the result only as an educational explanation of how clinicians assess treatment response; it should not replace specialist evaluation or decisions about corticosteroids, transplantation, or other care.
Accuracy and Limitations
The calculator reproduces the standard Lille logistic model using the entered age, albumin, bilirubin values, prothrombin time, and a renal-insufficiency indicator derived from serum creatinine. Its estimate is sensitive to the accuracy and timing of laboratory measurements, particularly the requirement for a bilirubin value obtained approximately seven days after treatment begins. The 0.45 cutoff is a prognostic aid rather than an absolute treatment rule, and the score does not account for infection, ongoing alcohol use, encephalopathy, hemodynamic instability, transplant eligibility, or other causes of liver injury. Clinical decisions should therefore be made by the treating specialist using the complete clinical picture.
Quick Examples
Example #1: Strong Treatment Responder
Example of a patient with improving bilirubin and relatively preserved renal function during corticosteroid treatment assessment.
Example #2: Poor Treatment Responder
Example of severe alcoholic hepatitis with persistent hyperbilirubinemia, renal impairment, and prolonged prothrombin time.
Example #3: Intermediate Clinical Picture
Example with moderate baseline disease and a partial bilirubin response after seven days of treatment.
